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Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is a major talking point as the community keenly watches for a decisive move above a critical resistance level, with many anticipating a rally beyond previous highs. This upward momentum is fueled by positive sentiment around increasing institutional demand, progress toward regulatory clarity, and macroeconomic signals like cooling inflation. However, some market participants remain cautious, suggesting potential rejections at current levels before any sustained breakout.

Ethereum is a global, open-source platform for decentralized applications. In other words, it is a decentralized blockchain platform that enables developers to build and deploy smart contracts and applications without central authority control. Unlike Bitcoin, which primarily functions as digital currency, Ethereum operates as a programmable global computer where developers can create any type of decentralized service.   The platform hosts over $14 billion in DeFi applications with hundreds of thousands of active users across financial protocols, NFT marketplaces, and gaming platforms. Its transition to Proof of Stake in September 2022 reduced energy consumption by over 99%, addressing environmental concerns while strengthening network security.  The network operates through thousands of independent validator nodes that process transactions and execute smart contracts on the Ethereum Virtual Machine. Smart contracts are self-executing programs written in Solidity that automatically carry out agreements when conditions are met, eliminating intermediaries like banks or brokers.   Validators stake ETH as collateral to propose and validate blocks, earning rewards for honest participation while facing penalties for malicious behavior. The EIP-1559 upgrade introduced a dynamic base fee mechanism that burns ETH with each transaction, creating deflationary pressure during high network activity when more ETH is burned than issued to validators.  Vitalik Buterin proposed Ethereum in 2013, but seven co-founders helped build it, including Gavin Wood who created Solidity and the EVM technical specification, and Joseph Lubin who founded ConsenSys. The project launched in July 2015 after raising over $18 million through crowdfunding, quickly becoming the largest blockchain developer community. Major milestones include the 2020 Beacon Chain launch, the 2021 London hard fork implementing fee burning, and the 2022 Merge to Proof of Stake.   Ether (ETH) serves multiple functions: paying transaction fees (gas), staking to secure the network and earn 3-5% annual yields, serving as collateral in DeFi protocols, and purchasing NFTs and digital assets. The asset is increasingly adopted by traditional institutions, with publicly traded companies adding ETH to corporate treasuries to generate staking yields while maintaining blockchain exposure, and in 2024, the SEC approved spot Ethereum ETFs, allowing traditional investors to gain exposure through conventional brokerage accounts.  Ethereum's roadmap focuses on dramatically increasing transaction capacity to over 100,000 per second, reducing confirmation times, and enhancing decentralization while maintaining security against future threats like quantum computing.

Ethereum

Ethereum is capturing significant attention following a notable price rally, driven by increasing institutional staking activity and fresh optimism surrounding potential spot ETF approvals. The community is buzzing with short squeeze narratives and growing confidence in Ethereum's pivotal role in DeFi, stablecoins, and the broader tokenization of real-world assets, anticipating further upside.

Bitmine Immersion Technologies, Inc. is a technology company focused on acquiring, holding, and actively managing ETH as its primary treasury reserve asset. It prioritizes digital ecosystem services, such as consultancy and advisory works. The company was founded on August 16, 1995 and is headquartered in Las Vegas, NV.

BitMine Immersion Technologies Inc

Bitmine Immersion Technologies Inc

Bitmine Immersion Technologies Inc. ($BMNR) is a major focus for investors due to an impending shareholder vote on a significant increase in authorized shares and executive compensation, generating intense debate. Many retail investors voice strong concerns about potential massive dilution and the stock's notable underperformance relative to Ethereum's price movements, leading to widespread criticism of management. The community is actively discussing whether this vote will enable future growth through its Ethereum staking strategy or further erode shareholder value.

TG Therapeutics, Inc. engages in the acquisition, development, and commercialization of novel treatments for B-cell malignancies and autoimmune diseases. Its product pipeline includes TG-1501, TG-1701, Ublituximab, and Umbralisib. The company was founded by Michael Sean Weiss and Laurence H. Shaw on May 18, 1993 and is headquartered in Morrisville, NC.

TG Therapeutics Inc

TG Therapeutics is trending as strong preliminary Q4 2025 results and an optimistic 2026 revenue outlook, including a potential path to $1 billion in Briumvi global sales, drive conversation following its JPM Healthcare Conference presentation. Investors are largely bullish on Briumvi's best-in-class profile and competitive advantages, especially after setbacks for rival drugs, yet many express frustration over sustained short interest and the stock's valuation, fueling active speculation around potential acquisition or continued organic growth.

Dogecoin is a cryptocurrency based on the popular "Doge" Internet meme and features a Shiba Inu on its logo. Dogecoin is a Litecoin fork. Introduced as a "joke currency" on 6 December 2013, Dogecoin quickly developed its own online community and reached a capitalization of US$60 million in January 2014. Compared with other cryptocurrencies, Dogecoin had a fast initial coin production schedule: 100 billion coins were in circulation by mid-2015, with an additional 5.256 billion coins every year thereafter. As of 30 June 2015, the 100 billionth Dogecoin had been mined.   Dogecoin was created by Billy Markus from Portland, Oregon and  Jackson Palmer from Sydney, Australia. Both wanted to create a fun cryptocurrency that will appeal beyond the core Bitcoin audience. Dogecoin is primarily used as a tipping system on Reddit and Twitter where users tip each other for creating or sharing good content. The community is very active in organising fundraising activities for deserving causes.  The developers of Dogecoin haven’t made any major changes to the coin since 2015. This means that Dogecoin could get left behind and is why Shibas are leaving Dogecoin to join more advanced platforms like Ethereum. One of Dogecoin strengths is its relaxed and fun-loving community. However, this is also a weakness because other currencies are way more professional.  To purchase Dogecoin, it involves downloading a crypto wallet, setting up a crypto exchange account and then trading away for your desired crypto currency. Once we have set up an account with a DOGE currency exchange and deposited some funds, you are ready to start trading.

Dogecoin

Dogecoin is trending amidst strong speculative interest, fueled by discussions of positive technical indicators and reports highlighting its outperformance against Bitcoin and Ethereum. The community maintains a fervent 'buy the dip' mentality, anticipating a significant price rally driven by its meme coin status and broader crypto market movements.

Ripple is the catchall name for the cryptocurrency platform, the transactional protocol for which is actually XRP, in the same fashion as Ethereum is the name for the platform that facilitates trades in Ether. Like other cryptocurrencies, Ripple is built atop the idea of a distributed ledger network which requires various parties to participate in validating transactions, rather than any singular centralized authority. That facilitates transactions all over the world, and transfer fees are far cheaper than the likes of bitcoin. Unlike other cryptocurrencies, XRP transfers are effectively immediate, requiring no typical confirmation time.  Ripple was originally founded by a single company, Ripple Labs, and continues to be backed by it, rather than the larger network of developers that continue bitcoin’s development. It also doesn’t have a fluctuating amount of its currency in existence. Where bitcoin has a continually growing pool with an eventual maximum, and Ethereum theoretically has no limit, Ripple was created with all of its 100 billion XRP tokens right out of the gate. That number is maintained with no mining and most of the tokens are owned and held by Ripple Labs itself — around 60 billion at the latest count.  Even at the recently reduced value of around half a dollar per XRP, that means Ripple Labs is currently sitting on around $20 billion worth of the cryptocurrency (note: Ripple’s price crashed hard recently, and may be worth far less than $60 billion by time you read this). It holds 55 billion XRP in an escrow account, which allows it to sell up to a billion per month if it so chooses in order to fund new projects and acquisitions. Selling such an amount would likely have a drastic effect on the cryptocurrency’s value, and isn’t something Ripple Labs plans to do anytime soon.  In actuality, Ripple Labs is looking to leverage the technology behind XRP to allow for faster banking transactions around the world. While Bitcoin and other cryptocurrencies are built on the idea of separating financial transactions from the financial organizations of traditional currencies, Ripple is almost the opposite in every sense.  XRP by Ripple price can be found on this page alongside the market capitalization and additional stats.

Ripple

XRP is generating buzz due to ongoing discussions around the anticipated Digital Asset Market Clarity Act markup and reports of Ripple's stablecoin, RLUSD, being utilized by major financial institutions like BlackRock. While many in the community anticipate significant gains from increased institutional adoption and regulatory clarity, there's notable frustration over XRP's price lagging behind Bitcoin, sparking ongoing debates about market manipulation and its potential for independent movement.

Super Micro Computer, Inc. engages in the distribution and manufacture of information technology solutions and other computer products. Its products include twin solutions, MP servers, GPU and coprocessor, MicroCloud, AMD solutions, power supplies, SuperServer, storage, motherboards, chassis, super workstations, accessories, SuperRack and server management products. The company was founded by Charles Liang, Yih-Shyan Liaw, Sara Liu, and Chiu-Chu Liu Liang in September 1993 and is headquartered in San Jose, CA.

Super Micro Computer Inc

SMCI is trending as a major financial institution recently initiated coverage with a "Sell" rating, citing concerns over shrinking margins in the AI server market despite the company's strong revenue growth and leadership in AI infrastructure. The community is fiercely debating this assessment, with many accusing the institution of manipulation to acquire shares at a discount ahead of anticipated strong earnings, while others remain cautious, pointing to ongoing profitability and governance challenges.

Strategy, Inc. engages in the provision of enterprise analytics and mobility software. The firm designs, develops, markets, and sells software platforms through licensing arrangements and cloud-based subscriptions and related services. Its product packages include Hyper. The company was founded by Michael J. Saylor and Sanjeev K. Bansal on November 17, 1989, and is headquartered in Vienna, VA.

Strategy Inc. - Ordinary Shares - Class A

Strategy

MicroStrategy is actively trending after its recent substantial Bitcoin acquisition, intensifying the ongoing debate around its unique corporate strategy. Bulls are rallying, anticipating a significant short squeeze and higher valuations, while a skeptical segment of the community questions the long-term impact of continuous share issuance to fund these large crypto purchases.

Netflix, Inc. engages in providing entertainment services. It also offers activities for leisure time, entertainment video, video gaming, and other sources of entertainment. It operates through the United States and International geographic segments. The company was founded by Marc Randolph and Wilmot Reed Hastings on August 29, 1997 and is headquartered in Los Gatos, CA.

Netflix Inc.

Netflix Inc

Netflix is trending due to reports of considering an all-cash bid for Warner Bros. Discovery, which the community is largely viewing as a bullish signal for avoiding dilution and indicating strong upcoming earnings. This comes amid an escalating takeover battle with Paramount, while many anticipate a pre-earnings rally or short squeeze ahead of its highly awaited report.

Adobe, Inc. is a global technology company, which engages in the provision of digital marketing and media solutions. It operates through the following segments: Digital Media, Digital Experience, and Publishing and Advertising. The Digital Media segment offers products and services that enable individuals, teams, businesses, and enterprises to create, publish, and promote content anywhere and accelerate productivity by transforming view, share, engage with and collaborate on documents and creative content. The Digital Experience segment focuses on integrated platform and set of products, services, and solutions that enable businesses to create, manage, execute, measure, monetize, and optimize customer experiences that span from analytics to commerce. The Publishing and Advertising segment includes legacy products and services that address diverse market opportunities, including eLearning solutions, technical document publishing, web conferencing, document and forms platform, web app development, high-end printing, and Adobe Advertising offerings. The company was founded by Charles M. Geschke and John E. Warnock in December 1982 and is headquartered in San Jose, CA.

Adobe Inc

Adobe is trending amid a barrage of analyst downgrades, as concerns over a challenging AI technology transition and intensifying competition from rival creative software and AI tools fuel a heated debate among investors. While many view the stock as overvalued and vulnerable to disruption, a significant segment of the community sees the recent dip as a compelling buying opportunity, emphasizing Adobe's strong fundamentals and strategic AI integrations for long-term growth.

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Compugen (CGEN) Reports Q1 Loss, Misses Revenue Estimates

Mersana Therapeutics, Inc. (MRSN) Reports Q1 Loss, Lags Revenue Estimates

MeiraGTx Holdings PLC (MGTX) Reports Q1 Loss, Misses Revenue Estimates

Shares of Affimed N.V. (AFMD) were in the spotlight on Monday morning after the company received a notice from Nasdaq indicating a compliance issue with its stock price.Affirmed <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/04/21/3064526/0/en/Affimed-Announces-Receipt-of-NASDAQ-Deficiency-Notice-Regarding-Minimum-Bid-Price-Requirement.html">said</a> that the Nasdaq notice indicated the bid price for the company’s common shares had closed below the minimum $1.00 per share requirement for continued listing on the bourse.Affirmed, headquartered in Mannheim, Germany, stated that it has been granted an initial period of 180 calendar days, or until October 13, 2025, to regain compliance.The company said that if it fails to regain compliance with the Minimum Bid Price Rule during the period, it may consider applying to transfer its securities from The Nasdaq Global Select Market to The Nasdaq Capital Market, provided that it meets the requirements.Affirmed also added that there is no assurance that Nasdaq would grant the company’s request for continued listing in the case.In the meantime, the firm intends to monitor the bid price of its common shares and consider available options to regain compliance with the Minimum Bid Price Rule.Affimed is a clinical-stage company aimed at developing treatments for cancer. In December, the company announced positive updates from a trial of its AFM24 in combination with atezolizumab in Non-Small Cell Lung Cancer patients.AFM24 is an innate cell engager molecule that activates the innate immune system to kill cancer cells.On Stocktwits, retail sentiment regarding Affimed remained unchanged within ‘neutral’ territory over the past 24 hours, while message volume remained at ‘extremely low’ levels.<figure class="image"><img style="aspect-ratio:648/146;" src="https://news.stocktwits-cdn.com/Screenshot_2025_04_21_at_7_06_18_AM_png_68fb6a412b.webp" alt="AFMD's Sentiment Meter and Message Volume as of 7:20 a.m. ET on April 21, 2025 | Source: Stocktwits" width="648" height="146"><figcaption>AFMD's Sentiment Meter and Message Volume as of 7:20 a.m. ET on April 21, 2025 | Source: Stocktwits</figcaption></figure><a href="https://stocktwits.com/symbol/AFMD">AFMD stock</a> is down by about 46% so far this year and by over 85% over the past 12 months.Also See: <a href="https://stocktwits.com/news-articles/markets/equity/dhl-freezes-shipments-worth-over-800-to-us-consumers-amid-rising-trade-tensions/chQiW2kRbQO">DHL Freezes Shipments Worth Over $800 To US Consumers Amid Rising Trade Tensions</a>For updates and corrections, email newsroom[at]stocktwits[dot]com&nbsp;

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Affimed Receives Nasdaq Deficiency Notice Over Low Share Price: Retail’s In Wait-And-Wait Mode

The company has been granted an initial period of 180 calendar days, or until October 13, 2025, to regain compliance with Nasdaq’s Minimum Bid Price Rule.

Equity

Affimed NV is a clinical-stage immuno-oncology company, which engages in the discovery and development of cancer immunotherapies. The company’s proprietary ROCK platform enables a tumor-targeted approach to recognize and kill a range of hematologic and solid tumors, enabling a broad pipeline of wholly-owned and partnered single agent and combination therapy programs. It operates through the Germany and USA geographical segments. The company was founded in 2000 and is headquartered in Mannheim, Germany.

Affimed N.V.

Short-Term Volatility, Then Markets Move On

Sustained Risk-Off Until Fed Path Is Clear

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Markets pulled back after reports that the DOJ opened a criminal investigation into Federal Reserve Chair Jerome Powell, raising concerns about central bank independence. With rate cuts, inflation, and political pressure all in focus, how do you think this standoff will impact markets in 2026?

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Fiscal Period	Estimated	Reported	Surprise	Result
Q1 '25	-$0.40	--	--	N/A
Q4 '24	-$0.65	--	--	N/A
Q3 '24	-$1.03	-$1.10	-6.47%	MISSED
Q2 '24	-$1.08	-$1.07	1.61%	BEAT
Q1 '24	-$1.66	-$1.41	15.36%	BEAT

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