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Novavax, Inc. Is a biotechnology company, which engages in the discovery, development, and commercialization of recombinant vaccines. The company was founded in 1987 and is headquartered in Gaithersburg, MD.

Novavax, Inc.

Novavax Inc

Novavax is trending after announcing a non-exclusive license agreement with Pfizer for its Matrix-M adjuvant, providing significant validation for the technology. This deal, building on previous collaborations, is driving community excitement and fueling discussions about the adjuvant's potential applications and the company's future partnerships amidst notable short interest.

Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is driving significant conversation as escalating US-EU trade tensions, particularly over Greenland and proposed tariffs, spark widespread market uncertainty and a risk-off shift. The community is sharply divided, with intense debate over whether current volatility signals a deeper correction or presents a key buying opportunity amidst ongoing institutional interest and broader macroeconomic shifts.

ProShares Trust - ProShares Ultra Bloomberg Natural Gas 2x Shares

ProShares Ultra Bloomberg Natural Gas

BOIL is currently experiencing a significant surge, fueled by an intense Arctic air invasion across the United States that is driving up natural gas demand and futures prices. The strong upward momentum has triggered a notable short squeeze, with the community actively discussing substantial profits and anticipating continued upside as extreme cold weather is projected to persist. This volatility is characteristic of the 2x leveraged ETF, attracting both profit-takers and those eyeing further gains.

Netflix, Inc. engages in providing entertainment services. It also offers activities for leisure time, entertainment video, video gaming, and other sources of entertainment. It operates through the United States and International geographic segments. The company was founded by Marc Randolph and Wilmot Reed Hastings on August 29, 1997 and is headquartered in Los Gatos, CA.

Netflix Inc.

Netflix Inc

Netflix is currently a major talking point among investors, primarily driven by its upcoming earnings report and the proposed all-cash acquisition of Warner Bros. Discovery assets, which has sparked a debate over potential growth versus debt concerns. The community is closely watching for strong ad-tier performance and subscriber metrics, particularly after a previous tax-related earnings miss, with sentiment split on whether recent oversold conditions signal a significant rebound or continued volatility.

ImmunityBio, Inc. is a clinical stage immunotherapy company. It develops next generation therapies that drive immunogenic mechanisms for defeating cancers and infectious diseases. The company's immunotherapy platform activates both the innate and adaptive immune systems to create long term immunological memory. ImmunityBio was founded by Patrick Soon-Shiong in 2014 and is headquartered in San Diego, CA.

ImmunityBio Inc

ImmunityBio is generating significant buzz following positive regulatory advancements for its ANKTIVA therapy, with the FDA outlining a path to resubmission for papillary bladder cancer that requires no new clinical trials. This news, combined with recent international approvals, is fueling strong community sentiment around the potential for a "cancer cure" and intense discussions anticipating a substantial short squeeze.

SSgA Active Trust - SPDR S&P 500 ETF Trust

The SPY is trending as market participants react to heightened geopolitical tensions, specifically former President Trump's recent tariff threats against NATO allies over Greenland and an anticipated Supreme Court ruling on presidential tariff authority. This has sparked a fierce debate among investors, with some advocating to "buy the dip" and anticipating a rapid "Taco Trade" rebound, while others warn of a significant market correction. Adding to the volatility are concerns surrounding Japan's bond market instability, creating a complex and uncertain trading environment.

AppLovin Corp. engages in the development and operation of a mobile marketing platform. It offers AppDiscovery, MAX, Adjust, and SparkLabs. Its software-based platform caters to mobile application developers to improve the marketing and monetization of applications. The company was founded by Andrew Karam, John Krystynak, and Adam Foroughi in 2011 and is headquartered in Palo Alto, CA.

Applovin Corp - Ordinary Shares - Class A

Applovin Corp

Applovin ($APP) is experiencing significant volatility and a notable price decline following a new short report alleging the company's involvement in money laundering. This report has sparked intense debate among investors, with many attributing the drop to market manipulation and viewing it as a buying opportunity, while others express concern over the serious accusations despite recent bullish analyst upgrades.

Corvus Pharmaceuticals, Inc. engages in the development of immune modulator product candidates with the potential to treat solid cancers, T-cell lymphomas, autoimmune diseases, and infectious diseases. Its product pipeline includes B Cell Activator and Anti-CD73, Adenosine Production Inhibitor Anti-CD73, ITK Inhibitor, A2AR Inhibitor, Anti-CXCR2, and A2BR Inhibitor. The company was founded by Richard A. Miller, Peter A. Thompson, Joseph J. Buggy, and Erik Verner on January 27, 2014 and is headquartered in South San Francisco, CA.

Corvus Pharmaceuticals Inc

Corvus Pharmaceuticals is trending due to overwhelmingly positive data from its Phase 1 clinical trial of soquelitinib for atopic dermatitis, with community discussions highlighting its strong efficacy in treatment-resistant patients. Investors are actively debating the potential for this novel oral ITK inhibitor to disrupt the significant atopic dermatitis market, fueling speculation of future partnerships or an acquisition and validating its broader immune-modulating platform.

BlackRock Institutional Trust Company N.A. - iShares 20+ Year Treasury Bond ETF

iShares 20+ Year Treasury Bond ETF

TLT is experiencing significant volatility amid escalating geopolitical tensions, notably the US asserting control over Venezuela's oil and ongoing debates surrounding US tariffs, fueling a "flight to quality" narrative for some. The community is actively discussing whether these events, alongside large institutional bond purchases, will continue to boost Treasuries as a safe haven or intensify concerns over US debt and the Federal Reserve's independence.

ProShares Trust - ProShares UltraShort Bloomberg Natural Gas -2x Shares

ProShares UltraShort Bloomberg Natural Gas

KOLD is trending as natural gas prices sharply reverse, primarily driven by dramatically warmer weather forecasts that are erasing previous cold-snap gains. The community is actively discussing the extreme volatility and "widow maker" nature of natural gas ETFs, with many attempting to capitalize on KOLD's rapid ascent amidst widespread price uncertainty. This significant shift in winter weather expectations is compelling traders to adjust positions, leading to rapid price movements in inverse natural gas products.

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<ul class="summary-bullets"><li>ANKTIVA is an Interleukin-15 (IL-15) receptor agonist that helps develop and activate key cells that work to destroy cancer cells.</li><li>The company presented an overview of the clinical status of its papillary disease program, including more than five years of follow-up data.</li><li>The data demonstrated strong bladder preservation outcomes.</li></ul>ImmunityBio (IBRX) shares rose 6% in pre-market trading on Tuesday after the United States Food and Drug Administration (FDA) outlined a pathway for resubmitting its supplemental biologics license application (sBLA) for ANKTIVA in Bacillus Calmette Guérin (BCG)-unresponsive papillary bladder cancer, without requesting new trials.&nbsp;The company said it recently met with the FDA for a Type B end-of-phase meeting to review data spanning over five years.<h2 class="st-heading-2">The FDA Meeting</h2>During the meeting, ImmunityBio presented more than five years of follow-up data supporting the papillary disease indication. Long-term results, published in The Journal of Urology, showed bladder cancer–specific survival of around 96% at three years, with median survival not yet reached.The data also demonstrated strong bladder preservation outcomes, with cystectomy avoidance rates of 92% at one year and 82% at three years, alongside a safety profile consistent with ANKTIVA’s currently approved use in carcinoma in situ (CIS).Based on these discussions, the FDA recommended that ImmunityBio submit additional information for further evaluation to potentially support a resubmission of the sBLA initially filed in 2025. The Agency did not request any new clinical trials.“We have completed the assembly and analysis of the requested additional information and will submit it within the next 30 days for the Agency’s review,” said Richard Adcock, President and CEO of ImmunityBio.ANKTIVA is an Interleukin-15 (IL-15) receptor agonist. IL-15 is an immune system protein that helps develop and activate key cells that work to destroy cancer cells. It is already commercially available in the U.S. for NMIBC CIS, with or without papillary tumors, and has received approvals in the U.K. and Saudi Arabia, as well as conditional approval in the European Union.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>Retail sentiment on Stocktwits for <a href="https://stocktwits.com/symbol/IBRX">IBRX</a> remained in the ‘extremely bullish’ territory over the past 24 hours, amid ‘extremely high’ message volumes. IBRX was among the top trending tickers on the platform at the time of writing.<img src="https://news.stocktwits-cdn.com/IBRX_jpg_704152379c.webp" alt="IBRX.jpg">One user laid out the potential triggers for the stock.<stembedurl>https://stocktwits.com/end2war/message/642249657</stembedurl>Over the past year, the stock has gained 85,% and year-to-date, it has added more than 173%.Read also: <a href="https://stocktwits.com/news-articles/markets/equity/why-did-rapt-stock-surge-63-in-pre-market-today/cmUuK0vR4aO">Why Did RAPT Stock Surge 63% In Pre-Market Today?</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, an ImmunityBio company logo is seen displayed on a smartphone screen. (Photo Illustration by Piotr Swat/SOPA Images/LightRocket via Getty Images)

IBRX Stock Extends Rally On FDA Feedback For ANKTIVA Bladder Cancer Filing

The company said it recently held end-of-phase talks with the United States Food and Drug Administration on its ANKTIVA application for treatment-resistant papillary bladder cancer.

This FDA Signal Is Powering IBRX Stock's Pre-Market Jump

Equity

<ul class="summary-bullets"><li>Analysts on average were expecting the company to report revenue of only $35.99 million for Q4, according to data from Fiscal AI.</li><li>The company’s revenue growth in the quarter was spurred by the accelerating adoption for Anktiva, CEO Richard Adcock said.</li><li>The company said that the Anktiva’s sales momentum “continues to trend upward.”</li></ul>Shares of ImmunityBio, Inc. (IBRX) jumped 28% on Thursday after the company said that it expects net product revenue of approximately $38.3 million for the fourth quarter of 2025, more than five times the revenue it reported in the corresponding quarter of 2024.Analysts on average were expecting the company to report revenue of $35.99 million for the period, according to data from Fiscal.ai.ImmunityBio’s revenue growth in the quarter was spurred by the accelerating adoption for Anktiva, CEO Richard Adcock <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.businesswire.com/news/home/20260115898106/en/ImmunityBio-Reports-Continued-Execution-and-Sales-Momentum-With-%24113-Million-of-Preliminary-Net-Product-Revenuea-700-increase-year-over-year">said</a>. Anktiva is an FDA-approved immunotherapy for non-muscle invasive bladder cancer.<h2 class="st-heading-2">Anktiva Momentum Builds</h2>The company said that the Anktiva’s sales momentum “continues to trend upward.” For full year 2025, the company expects net product revenue of approximately $113.0 million, marking 700% increase year-over-year.Earlier this week, it was reported that the Saudi Food and Drug Authority approved ANKTIVA in combination with the BCG (Bacillus Calmette-Guérin) vaccine to treat adults with BCG-unresponsive non-muscle invasive bladder cancer carcinoma in situ. The agency also approved Anktiva in combination with an immune checkpoint inhibitor for the treatment of metastatic non-small cell lung cancer, marking the company’s first global approval for the indication.ImmunityBio added on Thursday that it ended the quarter with an estimated $242.8 million in cash, cash equivalents, and marketable securities as of December 31, 2025.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around IBRX stayed within the ‘extremely bullish’ territory over the past 24 hours, while message volume remained at ‘extremely high’ levels.A Stocktwits user said that they now see the stock price breaching the $4 threshold over strong revenue growth and cash on hand. They added that the approvals by the Saudi FDA is a “real catalyst.”<stembedurl>https://www.stocktwits.com/Sisib/message/641960731</stembedurl><a href="https://stocktwits.com/symbol/IBRX">IBRX stock</a> has gained 62% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/disc-medicine-sanofi-eli-lilly-shares-slip-on-reports-of-fda-increasing-review-time-for-drugs/cmU1rSfR4JO">Disc Medicine, Sanofi, Eli Lilly Shares Slip On Reports Of FDA Increasing Review Time For Drugs Granted Priority Review Vouchers</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

IBRX Stock Continues Rally — What’s Driving The Optimism Today?

ImmunityBio said that it expects net product revenue of approximately $38.3 million for the fourth quarter of 2025.

<ul class="summary-bullets"><li>TG Therapeutics CEO Michael S. Weiss said on Tuesday that the company continues to believe Briumvi has a “multi-billion dollar opportunity.” &nbsp;</li><li>In FY26, the company expects Briumvi’s U.S. revenue to come in between &nbsp;$825 million and $850 million, accounting for a major chunk of the company’s overall revenue. &nbsp;</li><li>Briumvi is a prescription medication used to treat adults with relapsing forms of multiple sclerosis (MS).</li></ul>Shares of TG Therapeutics Inc (TGTX) rallied 7% after hours on Tuesday after the company said that it now expects full year 2026 total global revenue of $875 million to $900 million, highlighting significant growth expectations for its blockbuster drug Briumvi.The company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://ir.tgtherapeutics.com/news-releases/news-release-details/tg-therapeutics-provides-preliminary-fourth-quarter-and-full-1">expects</a> total revenue for full year 2025 to be about $616 million, including $594 million from sales of its Briumvi in the U.S. This exceeds a Wall Street estimate of $606.03 million, according to data from Fiscal AI.<h2 class="st-heading-2">Briumvi Demand</h2>TG Therapeutics Michael S. Weiss said on Tuesday that the company continues to believe Briumvi has a “multi-billion dollar opportunity.” &nbsp;Briumvi is a prescription medication used to treat adults with relapsing forms of multiple sclerosis (MS). Multiple sclerosis (MS) is an autoimmune disease where the immune system attacks the myelin sheath, the protective covering of nerve cells in the brain and spinal cord. This damage disrupts nerve signals, leading to a wide range of neurological symptoms, including numbness, vision problems, and difficulties with balance, coordination, and walking.The company is now also looking to develop and seek approval for a subcutaneous formulation of the drug for ease of administration as compared to its intravenous infusion version. In FY26, the company expects Briumvi’s U.S. revenue to come at between $825 million and $850 million, accounting for a major chunk of the company’s overall revenue. &nbsp;“With significant market share capture since launch, we believe TG Therapeutics is well positioned to drive long-term revenue growth and cash flow. Additionally, our development programs for consolidated IV BRIUMVI dosing and self-administered subcutaneous form of BRIUMVI are expected to drive revenue acceleration over the short and mid-term if approved,” CEO Michael S. Weiss said.“In parallel, we plan to initiate multiple exploratory studies that could expand BRIUMVI beyond MS, providing an additional lever for growth and underscoring its potential as a ‘pipeline-in-a-product,’” he added.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around TGTX stayed within the ‘extremely bullish’ territory over the past 24 hours, while message volume stayed within ‘extremely high’ levels.A Stocktwits user opined that the company’s revenue estimates could exceed to touch $1 billion in FY26.<stembedurl>https://www.stocktwits.com/greko50/message/641718123</stembedurl>Yet another voiced optimism for increased profits per share.<stembedurl>https://www.stocktwits.com/neilinva/message/641717512</stembedurl><a href="https://stocktwits.com/symbol/TGTX">TGTX stock</a> is up by about 1% over the past 12 months.Read More: <a href="https://stocktwits.com/news-articles/markets/equity/uber-doordash-caused-5800-annual-tip-loss-for-delivery-workers-in-new-york-says-report/cmUXlzyR4IN">Uber, DoorDash Caused $5,800 Annual Tip Loss For Delivery Workers With Interface Design Changes In New York, Says City Report</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

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TGTX Rallies 7% After Hours On Revenue Estimates Based On Strong Briumvi Demand Through 2026

The company expects total revenue for full year 2025 to be about $616 million, including $594 million from sales of its Briumvi in the U.S.

<ul class="summary-bullets"><li>The timeline extension comes on the heels of the FDA requesting additional information to assess Filspari’s clinical benefit.</li><li>The company submitted responses and the agency determined that the responses constitute a major amendment to the application.&nbsp;</li><li>The FDA is now expected to decide on the application by April 13, 2026.</li></ul>Shares of Travere Therapeutics, Inc., (TVTX) traded 19% lower on Tuesday after the company announced that U.S. Food and Drug Administration (FDA) has extended the review timeline for its application seeking approval of Filspari in focal segmental glomerulosclerosis.The FDA is now <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://ir.travere.com/press-releases/news-details/2026/Travere-Therapeutics-Announces-FDA-Extends-Review-of-sNDA-for-FILSPARI-sparsentan-in-FSGS/default.aspx">expected</a> to decide on the application by April 13, 2026. The agency was initially expected to rule on the application by Jan. 13.<h2 class="st-heading-2">Why The Delay?</h2>The timeline extension comes on the heels of the FDA requesting additional information to assess Filspari’s clinical benefit. The company submitted responses, and the agency determined that the responses constitute a major amendment to the application, and extended the review timeline, the company said. The agency requested no additional information on the safety or manufacturing of Filspari, it added.According to Travere, Filspari would be the first medication indicated for focal segmental glomerulosclerosis if approved. FSGS is a kidney disease causing sclerosis, or scarring in some filters of the kidneys, leading to protein leakage, swelling, and potentially kidney failure.CEO Eric Dube said that the company remains committed to working with the FDA during the extension period and making preparations for a potential commercial launch.Filspari is also approved by the FDA to slow kidney function decline in adults with IgA nephropathy, a chronic autoimmune kidney disease where deposits of the immunoglobulin A (IgA) antibody build up in the kidney's filters, causing inflammation, scarring, and damage.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around TVTX stock jumped from ‘bullish’ to ‘extremely bullish’ territory over the past 24 hours, while message volume rose from ‘high’ to ‘extremely high’ levels.A Stocktwits user opined that the FDA would eventually reject the drug.<stembedurl>https://www.stocktwits.com/Steve_TheBull_Rogers/message/641686497</stembedurl>Another opined that the FDA wouldn’t have extended the review timeline if it was planning on a rejection.<stembedurl>https://www.stocktwits.com/apux/message/641686139</stembedurl><a href="https://stocktwits.com/symbol/TVTX">TVTX stock</a> has gained 48% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/fund-manager-flags-concerns-about-tesla-dwindling-delivery-numbers-high-pe-ratio/cmUXXNkR4Ia">Fund Manager Flags Concerns About Tesla’s Dwindling Delivery Numbers, Notes High P/E Ratio</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the Travere Therapeutics logo is seen displayed on a smartphone screen. (Photo Illustration by Thomas Fuller/SOPA Images/LightRocket via Getty Images)

Travere Therapeutics Stock Slumps After FDA Extends Drug Review Timeline To April: Retail Is Divided On Eventual Approval

According to Travere, Filspari would be the first medication indicated for focal segmental glomerulosclerosis if approved. 

<ul class="summary-bullets"><li>As per the deal, Bakkt will issue about 9.1 million shares of Class A common stock to DTR shareholders.&nbsp;</li><li>Acquisition of DTR advances Bakkt’s global stablecoin settlement and programmable payments strategy.&nbsp;</li><li>Separately, it said that it intends to change its corporate name to ‘Bakkt, Inc’ effective January 22, 2026.&nbsp;</li></ul>Shares of Bakkt (BKKT) rallied on Monday after it announced that it has agreed to acquire Distributed Technologies Research (DTR), a global stablecoin payment infrastructure provider.As per the deal, and as consideration for DTR, Bakkt will issue shares of its Class A common stock representing 31.5% of the “Bakkt Share Number,”. Bakkt will issue about 9.1 million shares of Class A common stock to DTR shareholders, it said in a statement.&nbsp;“We are pleased to welcome DTR to Bakkt,” said Colleen Brown, Director and member of the Special Committee of Bakkt’s Board of Directors. “This transaction accelerates Bakkt’s evolution toward programmable money and new-age global financial infrastructure and reflects a disciplined approach to capital allocation aligned with long-term platform value creation”.&nbsp;<h2 class="st-heading-2">Push Towards Stablecoin</h2>Acquisition of DTR advances Bakkt’s global stablecoin settlement and programmable payments strategy. Bakkt has been undergoing a strategic pivot in recent months to get into crypto space. It has also launched a crypto treasury.&nbsp;The firm sold its loyalty rewards business last year and began acquiring money transmitter licenses to facilitate crypto trading, transfers, and settlement. The company provides solutions that enable institutional participation in the digital asset economy — spanning Bitcoin, tokenization, stablecoin payments, and AI-driven finance.&nbsp;Bakkt announced that it intends to change its corporate name to ‘Bakkt, Inc’ effective January 22, 2026. The company expects to continue to trade on the New York Stock Exchange under the ticker symbol ‘BKKT’.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>Retail sentiment around BKKT trended in ‘extremely bullish’ territory amid ‘extremely high’ message volume.&nbsp;One user said that it will not sell the stock until at least it reaches $150.<stembedurl>https://stocktwits.com/Safetyisfirst/message/641569194</stembedurl>Another bullish user predicted the stock to touch $30 by the end of the week.<stembedurl>https://stocktwits.com/Egreenebacks/message/641557360</stembedurl>Shares of Bakkt have fallen 20% over the past year.&nbsp;For updates and corrections, email newsroom[at]stocktwits[dot]com. &nbsp;

In this photo illustration, the Bakkt Holdings logo is seen displayed on a smartphone screen. (Photo Illustration by Thomas Fuller/SOPA Images/LightRocket via Getty Images)

Bakkt Stock Rallies Nearly 20% - What’s Behind The Move?

Bakkt said it has agreed to acquire Distributed Technologies Research, a global stablecoin payment infrastructure provider. 

<ul class="summary-bullets"><li>On Thursday, Sellas said that it received approximately $26.5 million in proceeds from the exercise of common stock warrants.</li><li>SELLAS is currently evaluating Galinpepimut-S (GPS) as a potential maintenance therapy in patients with Acute Myeloid Leukemia who have achieved complete remission following second-line salvage therapy.</li><li>The ongoing GPS trial is an overall survival study and final analysis is expected once 80 deaths have occurred.</li></ul>Shares of SELLAS Life Sciences Group, Inc. (SLS) fell for the fourth straight session on Friday as investors resorted to profit taking amid dilution concerns.Shares of the company traded 13% lower at $3.34 at the time of writing, after <a href="https://stocktwits.com/news-articles/markets/equity/sls-stock-breaches-5-dollar-level-after-over-3-years/cmxuTsiR4RS">breaching</a> the $5 threshold for the first time in over three years earlier this week.On Thursday, Sellas said that it received approximately $26.5 million in proceeds from the exercise of common stock warrants. This is in addition to the company’s estimated cash and cash equivalents of $71.8 million as of December-end.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around SLS stayed within the ‘extremely bullish’ territory over the past 24 hours, while message volume stayed at ‘extremely high’ levels.A Stocktwits user expressed disappointment at the company diluting shares of the company by exercising warrants provided it has “sufficient cash” to carry out ongoing trials. However, they expect the price to be back up by February.<stembedurl>https://www.stocktwits.com/jackobull/message/641370638</stembedurl>Another, however, said that there is no “legitimate reason” to sell the stock. “...we longs know this is short lived. &nbsp;VERY short lived. &nbsp;It will explode upward from this oversold action,” they wrote.<stembedurl>https://www.stocktwits.com/Wut_About_Bob/message/641368167</stembedurl><h2 class="st-heading-2"> What Drove The Recent Rally?</h2>SELLAS is currently evaluating Galinpepimut-S (GPS) as a potential maintenance therapy in patients with Acute Myeloid Leukemia who have achieved complete remission following second-line salvage therapy. AML is a fast-growing cancer of the blood and bone marrow where immature white blood cells build up, crowding out healthy cells, leading to fatigue, infections, and bleeding.The ongoing GPS trial is an overall survival study, and final analysis is expected once 80 deaths have occurred. As of December 26, 72 deaths have occurred, the company <a href="https://stocktwits.com/news-articles/markets/equity/sellas-life-sciences-group-stock-soars-as-it-nears-final-analysis-in-cancer-study/cL7dROARExt">said</a> last month, highlighting that it had previously expected 80 patient deaths to occur by December end.“While the 80th event has not yet occurred, and we remain fully blinded, every passing month may increase the probability of a successful study as highlighted by key opinion leaders in our recent R&amp;D event. Conclusive data will follow the unblinding and analyses of the study results,” SELLAS CEO Angelos Stergiou said at the time. The announcement kickstarted a rally that mostly sustained through late December and early January.Last week, Maxim analyst Jason McCarthy noted that delays in an event-driven trial like SELLAS’ could be suggestive of extended survival benefit from GPS.Besides GPS, SELLAS has another experimental drug in its pipeline called SLS009 also being developed to target certain cancers.According to data from Koyfin, all three of the analysts covering SELLAS rate it ‘Buy’ or higher. The stock has an average price target of $6.83, hinting at significant potential upside.<a href="https://stocktwits.com/symbol/SLS">SLS shares</a> have nearly tripled over the past 12 months.Read More: <a href="https://stocktwits.com/news-articles/markets/equity/kalvista-pharmaceuticals-stock-rallies-after-hours-on-strong-genetic-disorder-drug-sales-kickstart/cmUbnxGR45Z">KalVista Pharmaceuticals Stock Rallies After Hours On Strong Genetic Disorder Drug Sales Kickstart</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Stock market down on a black background. | Image source: Yuichiro Chino via Getty Images

SELLAS Life Sciences Falls For Fourth Straight Session — What’s Driving The Sell Off?

Shares of the company traded 13% lower at $3.34 at the time of writing.

<ul class="summary-bullets"><li>Imcivree is Rhythm’s only approved drug and the company is now looking forward to an FDA approval for the drug in the treatment of acquired hypothalamic obesity.</li><li>The FDA is expected to rule on the company’s application by March 20, 2026.</li><li>The company is also exploring the drug’s potential in treating other rare diseases including congenital hypothalamic obesity and Prader-Willi Syndrome.</li></ul>Shares of Rhythm Pharmaceuticals, Inc. (RYTM) jumped 4% on Friday after the company reported preliminary full-year Imcivree revenue of approximately $194 million, marking a growth of about 50% from FY24.Fourth quarter Imcivree revenue is expected to be about $57 million, marking a quarter-on-quarter growth of 11%. Imcivree is Rhythm’s only approved drug and the company is now looking forward to an approval from the U.S. Food and Drug Administration (FDA) for the drug in the treatment of <a href="https://stocktwits.com/news-articles/markets/equity/rhythm-pharma-experimental-drug-yields-weight-reduction-in-brain-damage-related-obesity/chFy2A1R5KT">acquired hypothalamic obesity.</a>The FDA is expected to rule on the company’s application by March 20, 2026.<h2 class="st-heading-2">Imcivree’s Current Use</h2>Imcivree is currently approved by the FDA to reduce excess body weight and maintain weight reduction long term in adult and pediatric patients two years and older with syndromic or monogenic obesity due to Bardet-Biedl syndrome. Bardet-Biedl syndrome is a rare genetic disorder affecting multiple body systems, characterized by vision loss, obesity, kidney problems, genital abnormalities, and learning disabilities.About 70% of the drug’s revenue for the year and the fourth quarter came from U.S. sales, Rhythm said. The company is also exploring the drug’s potential in treating other rare diseases including congenital hypothalamic obesity and <a href="https://stocktwits.com/news-articles/markets/equity/rhythm-pharmaceuticals-stock-rises-after-positive-study-data-for-setmelanotide-in-treating-genetic-disorder/cLIxj7cREFG">Prader-Willi Syndrome</a> in addition to advancing its other experimental drugs Bivamelagon and RM-718 in acquired hypothalamic obesity.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around RYTM stock stayed within the ‘bearish’ territory over the past 24 hours, while message volume stayed at ‘low’ levels.A Stocktwits user opined that the preliminary revenue numbers put speculation of slowing revenue growth to rest.<stembedurl>https://www.stocktwits.com/Stonky_Mcprofitface/message/641320511</stembedurl><a href="https://stocktwits.com/symbol/RYTM">RYTM stock</a> has gained 80% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/general-motors-incurs-7.1-billion-in-charges-in-q4/cmUbl4LR451">General Motors Incurs $7.1B In Charges In Q4 Pertaining To Slowing EV Demand, China Business Restructuring</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the Rhythm Pharmaceuticals company logo is seen displayed on a smartphone screen. (Photo Illustration by Piotr Swat/SOPA Images/LightRocket via Getty Images)

RYTM Stock Jumps 4% On Imcivree Revenue Growth: Firm Awaits Approval In Acquired Hypothalamic Obesity By March

Fourth quarter Imcivree revenue is expected to be about $57 million, marking a quarter-on-quarter growth of 11%.

<ul class="summary-bullets"><li>KalVista launched Ekterly in the U.S. in July for the treatment of acute attacks of hereditary angioedema in adults and children aged 12 years and older.</li><li>Through the full year 2025, the company recorded global Ekterly revenue of $49 million.</li><li>Kalvista now plans to file a new drug application with the FDA for the drug in pediatric HAE patients aged 2 to 11 years in the third quarter of 2026.</li></ul>Shares of KalVista Pharmaceuticals, Inc. (KALV) jumped 14% after hours on Thursday after the company said that it recorded about $35 million in revenue from its one and only approved drug Ekterly in the fourth quarter, merely months after launch.KalVista <a href="https://stocktwits.com/news-articles/markets/equity/kalvista-gets-fda-approval-for-drug-in-treating-swelling-disorder/chFtmFCR57B">launched</a> Ekterly in the U.S. in July for the treatment of acute attacks of hereditary angioedema in adults and children aged 12 years and older. The company said that in the three months through the end of December, prescription refills surpassed initial prescriptions as the primary driver of revenue.Hereditary angioedema (HAE) is a rare genetic disease caused by deficiency or dysfunction of a protein called the C1 esterase inhibitor, where patients experience painful and debilitating attacks of tissue swelling in various locations of the body that can be life-threatening depending on the area affected.<h2 class="st-heading-2">Ekterly’s Edge</h2>Ekterly is the first and only oral on-demand treatment for HAE, KalVista said, setting it apart from other on-demand HAE treatment options approved in the U.S., which require intravenous or subcutaneous administration.Through the full year 2025, the company recorded global Ekterly revenue of $49 million. The drug is now approved in seven global markets including the U.S., United Kingdom, European Union, Switzerland, Australia, Singapore and Japan.“Fundamental demand has remained strong, with some effects from seasonal variability, and we are encouraged by the continued high level of interest in switching to EKTERLY,” CEO Ben Palleiko said. “Internationally, we are seeing strong uptake in Germany, with early prescribing behaviors mirroring the positive trends we observed in the US, and we expect to expand into other major markets during 2026.”Kalvista now plans to file a new drug application with the FDA for the drug in pediatric HAE patients aged 2 to 11 years in the third quarter of 2026. The company envisions launching the drug for the younger population in the U.S. in 2027.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around KalVista jumped from ‘bullish’ to ‘extremely bullish’ territory over the past 24 hours, while message volume stayed at ‘high’ levels.A Stocktwits user applauded the numbers as an “incredible start to Ekterly sales.” “This has a squeeze written all over it,” the user added.<stembedurl>https://www.stocktwits.com/pblegend66/message/641279255</stembedurl>Another user highlighted the drug’s potential and noted that the company could make as much as $340 million in revenue from the drug.<stembedurl>https://www.stocktwits.com/Biocontrol/message/641276040</stembedurl><a href="https://stocktwits.com/symbol/KALV">KALV stock</a> has gained 92% over the past 12 months.Read More: <a href="https://stocktwits.com/news-articles/markets/equity/general-motors-incurs-7.1-billion-in-charges-in-q4/cmUbl4LR451">General Motors Incurs $7.1B In Charges In Q4 Pertaining To Slowing EV Demand, China Business Restructuring</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Rising stock market chart on a trading board background.

KalVista Pharmaceuticals Stock Rallies After Hours On Strong Genetic Disorder Drug Sales Kickstart

Ekterly is the first and only oral on-demand treatment for HAE, KalVista said, setting it apart from other on-demand HAE treatment options approved in the U.S.

<ul class="summary-bullets"><li>MannKind is now eyeing a potential approval of its Afrezza inhalation powder for children and adolescents living with type 1 or type 2 diabetes.</li><li>H.C. Wainwright reiterated a ‘Buy’ rating on MannKind with an $11 price target after the company’s update.</li><li>The firm said it is positive on MannKind's outlook over the next two years, saying "very little value is ascribed to the multiple tailwinds that could be validated in 2026."</li></ul>MannKind Corporation (MNKD) on Thursday said that it expects two high potential launches going into 2026, driving investor optimism and sending shares up 2%.&nbsp; “With two high-potential launches on the horizon, 2026 is shaping up to be a catalyst-rich year that positions MannKind for long-term value creation,” CEO Michael Castagna<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2026/01/08/3215359/29517/en/MannKind-Provides-Business-Updates-and-2026-Growth-Drivers.html"> said,</a> while adding that the company closed 2025 “on a high note” with its acquisition of scPharmaceuticals.<h2 class="st-heading-2">MannKind’s Potential Launches</h2>MannKind is now eyeing a potential approval of its Afrezza inhalation powder for children and adolescents living with type 1 or type 2 diabetes. The U.S. Food and Drug Administration is expected to rule on the application by May 29 and if approved, it would be the first needle-free insulin option for pediatric patients in over 100 years of insulin therapy, the company said.The company is also eyeing approval for its FUROSCIX ReadyFlow Autoinjector, developed to deliver a subcutaneous furosemide injection in under 10 seconds as an investigational alternative to the FDA-approved FUROSCIX On-body Infusor. Furosemide is used for treatment of edema in adult patients with chronic heart failure (CHF) or chronic kidney disease (CKD).<h2 class="st-heading-2">Analyst Weighs In</h2>H.C. Wainwright reiterated a ‘Buy’ rating on MannKind with an $11 price target after the company’s update. The price target represents a potential upside of about 88% from the stock's closing price on Wednesday.&nbsp;The firm said it is positive on MannKind's outlook over the next two years, saying "very little value is ascribed to the multiple tailwinds that could be validated in 2026."<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around MNKD shares jumped from ‘neutral’ to ‘bullish’ territory over the past 24 hours while message volume rose from ‘normal’ to ‘high’ levels.A Stocktwits user dismissed the company’s Thursday update as “another pump and dump.”<stembedurl>https://www.stocktwits.com/Kool_Aid_Mann/message/641251643</stembedurl><a href="https://stocktwits.com/symbol/MNKD">MNKD stock</a> has dropped 3% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/ford-stock-rallies-on-piper-sandler-upgrade-plans-to-launch-autonomous-driving-on-30000-ev/cmUbiTNR45X">Ford Stock Rallies On Piper Sandler Upgrade, Plans To Launch Autonomous Driving On $30,000 EV</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

MannKind Rallies On Optimism Of Two Imminent Product Launches: Analyst Sees ‘Multiple Headwinds’ For Stock In 2026

The company’s CEO Michael Castagna said that with two high-potential launches on the horizon, 2026 is shaping up to be a catalyst-rich year that positions MannKind for long-term value creation. 

<ul class="summary-bullets"><li>Ibsrela achieved $274 million in revenue in 2025, representing 73% growth vs. 2024</li><li>The company expects 2029 IBSRELA revenue to be $1 billion.&nbsp;</li><li>It expects Ibsrela FY2026 revenue to be between $410 and $430 million, up 50% from 2025.&nbsp;</li></ul>Shares of Ardelyx rallied on Thursday after it announced its preliminary guidance for the fiscal year 2026 that buoyed retail traders.&nbsp;The company said that majority of its full-year 2026 revenue will come from its &nbsp;drug Ibsrela, a first-in-class therapy for irritable bowel syndrome with constipation. It expects revenue to be between $410 and $430 million, representing growth of at least 50% compared to 2025.The company said it expects its full-year 2026 Xphozah revenue is expected to be between $110 and $120 million. Ardelyx’s Xphozah is a FDA-approved drug that is given to lower phosphorus levels in adults with chronic kidney disease on dialysis.&nbsp;“We enter 2026 exceptionally well positioned to deliver significant growth and long-term value creation as we invest in our business to accelerate our commercial opportunities,” said Mike Raab, president and chief executive officer at Ardelyx.&nbsp;Shares in the company soared nearly 17% at the time of writing.&nbsp;<h2 class="st-heading-2">Ibsrela Potential</h2>Ardelyx launched Ibsrela in the U.S. in 2022 and has since been a success for the company. The company expects 2029 Ibsrela revenue to be $1 billion.&nbsp;The drug generated a revenue of about $87 million in the fourth quarter of 2025 compared to $53.8 million in the year-ago quarter. Ibsrela finished 2025 with full year revenue totaling approximately $274 million, 73% growth compared to 2024, it said.&nbsp;It also said that a late-stage clinical trial evaluating Ibsrela in patients with chronic idiopathic constipation (CIC) has commenced and is expected to be completed in the second half of 2027.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>Retail sentiment around ARDX trended in ‘extremely bullish’ territory amid ‘high’ message volume.&nbsp;One bullish user said the company is going to ‘overachieve’ in 2026.&nbsp;<a href="https://stocktwits.com/Bfunk17/message/641220312">https://stocktwits.com/Bfunk17/message/641220312</a>Another user said that their portfolio saw a big bounce due to the recent announcement.<a href="https://stocktwits.com/elisworld/message/641225054">https://stocktwits.com/elisworld/message/641225054</a>Shares of Ardenyx are up nearly 26% over the past year.&nbsp; &nbsp;

In this photo illustration, the Ardelyx logo is seen displayed on a smartphone screen. (Photo Illustration by Thomas Fuller/SOPA Images/LightRocket via Getty Images)

Ardelyx Stock Is Rallying – What Is Making Retail So Bullish?

The company said it made significant commercial progress in 2025, generating approximately $378 million in product revenue. 

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